Integrating Spatial Working Memory and Remote Memory: Interactions between the Medial Prefrontal Cortex and Hippocampus

In recent years, two separate research streams have focused on information sharing between the medial prefrontal cortex (mPFC) and hippocampus (HC). Research into spatial working memory has shown that successful execution of many types of behaviors requires synchronous activity in the theta range between the mPFC and HC, whereas studies of memory consolidation have shown that shifts in area dependency may be temporally modulated. While the nature of information that is being communicated is still unclear, spatial working memory and remote memory recall is reliant on interactions between these two areas. This review will present recent evidence that shows that these two processes are not as separate as they first appeared. We will also present a novel conceptualization of the nature of the medial prefrontal representation and how this might help explain this area’s role in spatial working memory and remote memory recall

Compacton Solutions in a Class of Generalized Fifth Order Korteweg-de Vries Equations

We study a class of generalized fifth order Korteweg-de Vries (KdV) equations which are derivable from a Lagrangian L(p,m,n,l) which has variable powers of the first and second derivatives of the field with powers given by the parameters p,m,n,l. The resulting field equation has solitary wave solutions of both the usual (non-compact) and compact variety ("compactons"). For the particular case that p=m=n+l, the solitary wave solutions have compact support and the feature that their width is independent of the amplitude. We discuss the Hamiltonian structure of these theories and find that mass, momentum, and energy are conserved. We find in general that these are not completely integrable systems. Numerical simulations show that an arbitrary compact initial wave packet whose width is wider than that of a compacton breaks up into several compactons all having the same width. The scattering of two compactons is almost elastic, with the left over wake eventually turning into compacton-anticompacton pairs. When there are two different compacton solutions for a single set of parameters the wider solution is stable, and this solution is a minimum of the Hamiltonian.Comment: 13 pages (8 embedded figures), RevTeX (plus macro), uses eps

Continuous Theta Rhythm During Spatial Working Memory Task in Rodent Models of Streptozotocin-induced Type 2 Diabetes

Alzheimer’s disease is a neurodegenerative disorder altering memory loss thought to be due to neuropathological symptoms such as the buildup of beta amyloid plaques (Ab) and neurofibrillary tangles (NFT). The etiology of Alzheimer’s is still unknown; however, potential risk factors such as diabetes may lead to its development. The most common form of diabetes is type 2 diabetes known for persistent insulin resistance leading to a state of hyperglycemia. Insulin resistance has been shown to affect cognitive abilities such as learning, memory and also alters synaptic plasticity. Neural connections between the hippocampus (HC) and anterior cingulate cortex (ACC) are known to be very important for learning and memory and are highly plastic, making them an intriguing target that could be altered by hyperglycemia. We hypothesize that hyperglycemic rodents will exhibit spatial memory deficits that may be associated with cognitively linked interactions between the HC and ACC. Minimal doses of streptozotocin (STZ), which is toxic to insulin producing beta cells, were given for 9-10 weeks. Using a spatial working memory task known as delayed alternation we found significant differences between control and experimental rats in working memory accuracy. This task places strong working memory demands on subjects which may be compromised by a hyperglycemic state. We measured EEG recordings from the HC and ACC during task performance and found that hyperglycemic rats had nearly continuous theta rhythm during the 30-minute session. Control rats however, displayed normal transitions between theta and lower frequency delta. Neural connectivity may be altered due to a change in frequency activity between the HC and ACC due to diabetes which is a risk factor in the development of AD impairments. These results show that hyperglycemia leads to changes along the circuit critical for learning and memory